Techniques:
- Shape descriptor distributions and comparison tool (pdf) (online tool)
Cells within a tissue may be nearly sphere-like or they may be quite elongated. How different do these 3D cell shapes look in a single cross-section though the tissue, as would be seen in a slice or confocal image? Very different, according to a model for 3D, isotropic, confluent cell packings. With this online tool, compare the distribution of your 2D cell shapes to the distributions from model imagery. - Engineering marrow-derived macrophages against solid tumors