News • PSOC@Penn researchers joined researchers and patient advocates from across the Physical Sciences - Oncology Network at the Annual Investigators Meeting in Minneapolis from September 18th-20th. Manasvita Vashisth (Ph.D. student, Discher group) gave an oral presentation and Larry Dooling (Postdoc, Discher group) and Alok Ghosh (Ph.D. student, Radhakrishnan group) gave lightning talks. PSOC@Penn presented ten posters with Larry Dooling and Eoin McEvoy (Postdoc, Shenoy group) winning poster awards. Special thanks to our hosts at the UMN PSOC. • Trainees from PSOC@Penn attended the annual joint Junior Investigators Meeting of the Physical Sciences - Oncology Network and Cancer Systems Biology Consortium at the NIH campus on August 22nd and 23rd. Jason Andrechak (Ph.D. student, Discher group) was selected to give an oral presentation.
• The PSOC@Penn Seminar Series resumes for the Spring semester on January 25, 2021. Talks are held via Zoom. Please email Manu Tewari (manu at seas.upenn.edu) for Zoom links. The full speaker schedule can be found here: PSOC@Penn -Spring 2021 Webinar Series
January 25, 2021
“Predicting interactions between cell collectives and their environment”
M. Lisa Manning, PhD
February 2, 2021
February 8, 2021
“Abnormal mechanics in brain tumors”
Meenal Datta, PhD
Massachusetts General Hospital
News Exosomal PD-L1 contributes to immunosuppresion - Dr. Wei Guo (08.08.2018) in NATURE - Highlighted (08.08.2018) by PENN TODAY Baking Soda May Clean Cancer’s (Circadian) Clock - Dr. Chi Van Dang in GEN News (05.31.2018) in CELL
Cancer Physics @ Penn
This ‘Cancer Physics’ Center at the University of Pennsylvania wants to engage interested students, faculty, and the public!
** We are now recruiting stellar students and postdoctoral fellows for various projects. We are keen to interact with other faculty who might have relevant interests and/or expertise. And we are also hoping to engage those in the greater Public with interest and resources to help in the pursuit of new directions and approaches in cancer research — all can help! **
A recent press release provides an initial overview of faculty involved in our Center.
The PSOC@Penn (Physical Sciences in Oncology Center at Penn) is funded by a 5-year NIH grant from the National Cancer Institute (NCI) to focus on physical changes of tissues, cells, and nuclei that contribute to cancer growth and initiation. As tumor cells divide, invade, and displace normal cells, the tissue often changes physically, frequently getting stiffer, sometimes softer, often heterogeneously. Physical changes sometimes occur even before the cancer is detectable. Primary liver cancer appears representative as it almost always arises in the setting of end-stage liver fibrosis, termed cirrhosis, that is caused by excess alcohol consumption among other causes. Measuring liver stiffness is now possible in living patients, and prospective studies show patients with stiffer livers have dramatically increased rates of liver cancer.
Our Center integrates cancer experts with physical scientists and engineers who conduct diverse biophysical experiments from tissue scale down to single molecules. Theorists take multi-scale approaches to clarifying and predicting biophysical phenomena. Primary liver cancer is a main focus – though not exclusive to our interests, and our ideas and tools seek to broadly advance modern diagnostics and drive new treatments.
This website will progressively add content to explain our project areas, personnel, and progress.