Cancer Physics Mondays @ Penn

Feb.5-10, 2017 Gordon Research Conference – Physical Science of Cancer: Cancer Forces, Structures, and Mathematical Predictions

** 2016 Fall PSOC@Penn Seminar Series **

Mondays @ Noon in 337 Towne (unless noted):

Oct. 10: David Kaplan, MD, Penn Sch Med Gastroenterology

Oct.17: Orion Weiner, PhD, UCSF Cardiovascular Res Inst

Oct.24: Tammy Chang, PhD, UCSF Surgery

Oct.31: Bojana Gligorijevic, PhDTemple Univ., Bioengineering

Nov.7: Wolfram Goessling, MD PhD, Harvard Med. Sch.

— Nov.18 (Friday 9am – 4pm): NCI Site Visit – 5000 Vagelos —

Nov.28: Matthieu Piel, PhD, Institut Curie – Subcellular Structure and Cellular Dynamics Unit

Dec.12: John F. Marko, PhD, Northwestern Univ., Molecular Biosciences, Physics


SUMMER 2016 Lect’s by Faculty & Fellows:    PSOC Noons in 5000 Vagelos

05.09.2016 Roger Greenberg, MD-PhD/UPENN
05.23.2016 Rachel Bennett, PhD  &  Andrea Liu/UPENN
06.13.2016 Vivek Shenoy PhD/UPENN
06.27.2016 Ravi Radhakrishnan, PhD/UPENN
07.11.2016 Wei Guo, PhD/UPENN
07.25.2016 PSOC WORKSHOP (3-6pm + food & drinks)
08.01.2016 Emma Furth, MD /UPENNcancelled
08.08.2016 Tobias Baumgart , PhD/UPENN
08.22.2016 Rebecca Wells, MD/UPENN
09.12.2016 Huaiying Zhang, PhD in Mike Lampson grp/UPENN


2016 Spring Seminar Series:

Dec 7, 12-1 pm: Herbert Levine, Rice Univ. PSOC Seminar, 337 Towne.

Jan 14 (not Mon) 10:30-12: Sanjay Kumar, UC Berkeley. BE seminar 337 Towne.

Jan 21 (not Mon) 10:30-12:  Mehmet Toner, Harvard. BE seminar, 337 Towne.

Jan 25, 12-1 pm: Ashani Weeraratna, Wistar Inst. PSOC Seminar, 337 Towne.

Feb 8, 12-1 pm: Edna Cukierman, Fox Chase. PSOC Seminar, 337 Towne.

Feb 15, 12-1 pm: Ingolf Sack, Berlin – Charite. PSOC Seminar, 337 Towne.

Mar 7, 12-1 pm: Roger Kamm, MIT. PSOC Seminar, 337 Towne.

Mar 21, 12-1 pm: James Duncan, Fox Chase. PSOC Seminar, 337 Towne.

Apr 11, 12-1 pm: Sharon Gerecht, Johns Hopkins. PSOC Seminar, 337 Towne.

Apr 25, 12-1 pm: Robert Gatenby, Moffitt Cancer Ctr. PSOC Seminar, 337 Towne.


Summer & Fall 2015 Lectures & Posts

Oct 12, 12-1: Paul Janmey (Project-1 PSOC@Penn ), Penn. PSOC Lecture 337 Towne.

Oct 12-13: ITMAT Symposium (some PSOC relevant talks).

Oct 26, 2-3: Tobias Baumgart (Project-2 PSOC@Penn), Penn. PMI Lecture, CRB Austrian Auditorium.

Oct 29 (not Mon), 10:30-12: Raj Vadigepalli , Jefferson. BE seminar 337 Towne

Nov 2, 12-1: Dennis Discher (Project-3 PSOC@Penn), Penn. PSOC Lecture 337 Towne. “From Nuclear Lamina Mechanosensitivity to DNA damage”

Nov 4 (not Mon), 4-5pm: Dan Needleman, Harvard U., Condensed Matter Seminar, David Rittenhouse Labs Rm.A4.

Nov 9, 12-1: Ravi Radhakrishnan, Wei Guo, & Project-2 Team, Penn. PSOC Lecture 337 Towne. “Can Soft Signals be Oncogenic?“Nov 10 (not Mon) 1-5 pm:  Chem Biophys Mini-Symposium with Keynote by Nathaniel Gray, Dana Farber Cancer Inst.

Nov 12, 12-1: Ravi Radhakrishnan, Penn. “Subcellular Physical Models in Oncology”  Radiation Oncology Dept. Seminar,Smilow Building, 8thfloor Seminar room 8-146AB.

Nov 23, 12-1: Andrea Liu & Vivek Shenoy (Theory Core PSOC@Penn), Penn. PSOC Lecture 337 Towne.

Nov 30 , 2-3: Vivek Shenoy (Theory Core PSOC@Penn), Penn. PMI Lecture, CRB Austrian Auditorium.


This ‘Cancer Physics’ Center at the University of Pennsylvania wants to engage interested students, faculty, and the public!

** We are now recruiting stellar students and postdoctoral fellows for various projects. We are keen to interact with other faculty who might have relevant interests and/or expertise. And we are also hoping to engage those in the greater Public with interest and resources to help in the pursuit of new directions and approaches in cancer research — all can help! **

A recent press release provides an initial overview of faculty involved in our Center.

The PSOC@Penn (Physical Sciences in Oncology Center at Penn) is funded by a 5-year NIH grant from the National Cancer Institute (NCI) to focus on physical changes of tissues, cells, and nuclei that contribute to cancer growth and initiation. As tumor cells divide, invade, and displace normal cells, the tissue often changes physically, frequently getting stiffer, sometimes softer, often heterogeneously. Physical changes sometimes occur even before the cancer is detectable. Primary liver cancer appears representative as it almost always arises in the setting of end-stage liver fibrosis, termed cirrhosis, that is caused by excess alcohol consumption among other causes. Measuring liver stiffness is now possible in living patients, and prospective studies show patients with stiffer livers have dramatically increased rates of liver cancer.

Liver cancer is often associated with a scarring type of response, as shown in red (image by Jerome Irianto).
Liver cancer is often associated with a scarring type of response, as shown in red (image by Jerome Irianto).

Our Center integrates cancer experts with physical scientists and engineers who conduct diverse biophysical experiments from tissue scale down to single molecules. Theorists take multi-scale approaches to clarifying and predicting biophysical phenomena. Primary liver cancer is a main focus – though not exclusive to our interests, and our ideas and tools seek to broadly advance modern diagnostics and drive new treatments.

This website will progressively add content to explain our project areas, personnel, and progress.

Nuclear envelopes of cells in Tumors and in Normal Liver (image by Jerome Irianto).
Nuclear envelopes of cells in thin slices of Tumors and Normal Liver (image by Jerome Irianto).