Irianto, J., C. Pfeifer, Y. Xia, D.E. Discher.
Break Induced Telomere Synthesis Underlies Homology Directed Telomere Maintenance.
Dilley RL, Verma P, Cho NW, Winters HD, Wondisford AR, and Greenberg RA.
Deletion mutations keep kinase inhibitors in the loop.
Freed, D. M. , J. H. Park, R. Radhakrishnan, M. A. Lemmon,
The Dark Side of Cell Signaling: Positive Roles for Negative Regulators.
Lemmon MA, Freed DM, Schlessinger J, Kiyatkin A.
Curvature-undulation coupling as a basis for curvature sensing and generation in bilayer membranes.
R. P. Bradley, R. Radhakrishnan,
Fibrous nonlinear elasticity enables positive mechanical feedback between cells and extracellular matrices.
S. Hall, F. Alisafaei, E. Ban, X. Feng, C. Y. Hui, V. B. Shenoy*, and M. Wu*.
Proceedings of the National Academy of Sciences Plus, in press 2016.
Nuclear constriction segregates mobile nuclear proteins away from chromatin.
Irianto J, Pfeifer CR, Bennett RR, Xia Y, Ivanovska IL, Liu AJ, Greenberg RA, Discher DE.
Molecular Biology of the Cell. 2016 [pre- print]
As a nucleus enters a small pore, chromatin stretches and maintains integrity even with DNA breaks.
Irianto, Y. Xia, C.R. Pfeifer, R.A. Greenberg, and D.E. Discher.
Sec3 promotes the binary t-SNARE complex assembly and membrane fusion.
Yue, P., Zhang, Y, Mei, K., Zhu, … and Guo, W.
NATURE COMMUNICATIONS (in press).
Zeng, J., Feng, S., Wu, B., and Guo, W.
“Cell Polarity” (Edited by Keith Mostov). Cold Spring Harbor Series (2016)
Oncogenic BRAF-mediated melanoma cell invasion.
Lu, H., Liu, S., Zhang, G., Kwong L., Zhu, Y., Miller, J.P., … and Guo, W.
Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis.
Zhang, C., Brown, M.Q., van de Ven, W., Zhang, Z.M., … Guo, W., … Raikhel, N.V.
PNAS (2016) 113, E41-50. (Featured in PNAS).
Normal and Fibrotic Rat Livers Demonstrate Shear Strain Softening and Compression Stiffening: a Model for Soft Tissue Mechanics.
Perepelyuk, L. Chin, X. Cao, A. V. Oosten, V. B. Shenoy, P. A. Janmey, and R. G. Wells.
PLOS ONE, DOI: 10.1371/journal.pone.0146588 JANUARY 2016
Mechanical signaling coordinates the embryonic heartbeat.
K.K. Chiou, J.W. Rocks, C. Yingxian Chen, S. Cho, K.E. Merkus, A. Rajaratnam, P. Robison, M. Tewari, K. Vogel, S.F. Majkut, B.L. Prosser, D.E. Discher, A.J. Liu.
Membrane shape instability induced by protein crowding.
Chen Z., Atefi E., Baumgart T.
Filomicelles from aromatic di-block copolymers increase paclitaxel-induced tumor cell death and aneuploidy compared to aliphatic copolymer.
P.R. Nair, K. S. Anbazhagan, K.R. Spinler, M.R. Vakili A. Lavasanifar, D.E. Discher.
Mechanotransduction In Cancer.
Chin, Y. Xia, D.E. Discher, P.A. Janmey.
Nuclear lamins in cancer.
Irianto, C. Pfeifer, I.L. Ivanovska, J. Swift, and D.E. Discher.
Thermodynamic free energy methods to investigate shape transitions in bilayer membranes.
N. Ramakrishnan, R. W. Tourdot, R. Radhakrishnan,
A chemo-mechanical model for nuclear morphology and stresses during cell transendothelial migration.
Cao, E. Moeendarbary, P. Isermann, P. M. Davidson, X. Wang, M. B. Chen, A. K. Burkart, J. Lammerding, R. D. Kamm, and V. B. Shenoy.
BIOPHYSICAL JOURNAL 111: 1541-1552, OCTOBER 2016
Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling.
S. Liu, H. Wang, C. R. Copeland, C. S. Chen, V. B. Shenoy*, and D. H. Reich*.
SCIENTIFIC REPORTS, 6:33919 SEPTEMBER, 2016
Response of biopolymer networks governed by the physical properties of cross-linking molecules.
Wei, Q. Zhu, J. Qian, Y. Lin, and V. B. Shenoy.
SOFT MATTER, 12:2537-2541 MARCH 2016
Detyrosinated Microtubules Buckle and Bear Load in Contracting Cardiomyocytes.
Robison, M. A. Caporizzo, H. Ahmadzadeh, A. I. Bogush, C. Y. Chen, K. B. Margulies, V. B. Shenoy, and B. L. Prosser.
SCIENCE, 352: 6284 APRIL 2016
Harnessing Cellular-Derived Forces in Self-Assembled Microtissues to Control the Synthesis and Alignment of ECM.
Y. Schell, B. T. Wilks, M. Patel, C. Franck, V. Chalivendra, X. Cao, V. B. Shenoy, and J. Morgan.
BIOMATERIALS, 77:120-129 JANUARY 2016
Jerome Irianto, Charlotte R Pfeifer, Yuntao Xia, Avathamsa Athirasala, Irena L Ivanovska, Roger A Greenberg, Dennis E Discher
bioRxiv 035626; doi: http://dx.doi.org/10.1101/035626
Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor.
P.C.D.P. Dingal, A.M. Bradshaw, S. Cho, M. Raab, A. Buxboim, J. Swift, and D.E. Discher.
Nature Materials 14: 951–960 (2015).
Stem cell mechanobiology – diverse lessons from bone marrow.
I.L. Ivanovska, J-W. Shin, J. Swift, and D.E. Discher.
Trends in Cell Biology 25:523-32 (2015).
Myosin-II repression favors pre/pro-platelets, but shear-activation generates platelets and fails in macrothrombocytopenia.
K.R. Spinler, J-W. Shin, M.P. Lambert, D.E. Discher.
Blood 125:525-33 (2015).
Cell Rigidity and Shape override CD47’s ‘Self’ signaling in Phagocytosis by Hyperactivating Myosin-II.
N.G. Sosale, T. Rouhiparkouhi, A.M. Bradshaw, R. Dimova, R. Lipowsky, and D.E. Discher.
Blood 125:542-52 (2015).
Cell-mediated fiber recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments.
Baker, B. Trappmann, W. Wang, M. S. Sakar, I. Kim, V. B. Shenoy, J. Burdick, and C. S. Chen
NATURE MATERIALS, 14, 1262-1268, 2015
ATM dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition.
Harding SM, Boiarsky J, and Greenberg RA.
Cell Reports S2211-1247 2015 (PMC4607662)
Mechanical effects of dynamic binding between tau proteins on axonal microtubules during traumatic brain injury: predictions from a computational model.
Ahmadzadeh, D. H. Smith, and V. B. Shenoy.
BIOPHYSICAL JOURNAL, 109(11):2328-2337, 2015
A chemo-mechanical model for extracellular matrix and nuclear rigidity regulated size of focal adhesion plaques.
Cao, Y. Lin, T. P. Driscoll, J. Franco-Barraza, E. Cukierman, R. L. Mauck, and V. B. Shenoy
BIOPHYSICAL JOURNAL, 109(9):1807-1817, 2015
A chemo-mechanical free-energy-based approach to model durotaxis and extracellular stiffness-dependent contraction and polarization of cells.
V.B. Shenoy, H. Wang and X. Wang.
JOURNAL OF THE ROYAL SOCIETY INTERFACE (FOCUS), 6: 20150067, 2015
Application of a free energy landscape approach to study tension dependent bilayer tubulation mediated by curvature inducing proteins,
R. W. Tourdot, N. Ramakrishnan, T. Baumgart, R. Radhakrishnan,
Physical Review E, 92, 042715. (2015)
Phenomenology based multiscale models as tools to understand morphological transitions in cell membranes.
Ramakrishnan, R. Radhakrishnan,
Advances in Planar Lipid Bilayers and Liposomes – Elsevier, 2015,
ISSN 1554-4516, Vol 22, pp 129-175. DOI: 10.1016/bs.adplan.2015.06.004