Mechanosensing matrix.

Irianto, J., C. Pfeifer, Y. Xia, D.E. Discher.

Cell 165: 1820 (2016).


Break Induced Telomere Synthesis Underlies Homology Directed Telomere Maintenance.

Dilley RL, Verma P, Cho NW, Winters HD, Wondisford AR, and Greenberg RA.

Nature October, 2016


Deletion mutations keep kinase inhibitors in the loop.

Freed, D. M. , J. H. Park, R. Radhakrishnan, M. A. Lemmon,

Cancer Cell 2016, 29(4):423-425.


The Dark Side of Cell Signaling: Positive Roles for Negative Regulators.

Lemmon MA, Freed DM, Schlessinger J, Kiyatkin A.

Cell 2016 Mar 10;164(6):1172-84.


Curvature-undulation coupling as a basis for curvature sensing and generation in bilayer membranes.

R. P. Bradley, R. Radhakrishnan,

Proceedings of the National Academy of Sciences Plus, 2016. 113: E5117-5124


Fibrous nonlinear elasticity enables positive mechanical feedback between cells and extracellular matrices.

S. Hall, F. Alisafaei, E. Ban, X. Feng, C. Y. Hui, V. B. Shenoy*, and M. Wu*.

Proceedings of the National Academy of Sciences Plus, in press 2016.


Nuclear constriction segregates mobile nuclear proteins away from chromatin.

Irianto J, Pfeifer CR, Bennett RR, Xia Y, Ivanovska IL, Liu AJ, Greenberg RADischer DE.

Molecular Biology of the Cell. 2016 [pre- print]


As a nucleus enters a small pore, chromatin stretches and maintains integrity even with DNA breaks.

Irianto, Y. Xia, C.R. Pfeifer, R.A. Greenberg, and D.E. Discher.

Biophysical Journal Letter for Special Issue on Chromatin Biophysics

(online Oct.2016).


Sec3 promotes the binary t-SNARE complex assembly and membrane fusion.

Yue, P., Zhang, Y, Mei, K., Zhu, … and Guo, W.



Polarized Exocytosis.

Zeng, J., Feng, S., Wu, B., and Guo, W.

Cell Polarity” (Edited by Keith Mostov). Cold Spring Harbor Series (2016)


Oncogenic BRAF-mediated melanoma cell invasion.

Lu, H., Liu, S., Zhang, G., Kwong L., Zhu, Y., Miller, J.P., … and Guo, W.

CELL REPORTS (2016) 15, 2012-2024.


Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis.

Zhang, C., Brown, M.Q., van de Ven, W., Zhang, Z.M., … Guo, W., … Raikhel, N.V.

PNAS (2016) 113, E41-50. (Featured in PNAS).


Normal and Fibrotic Rat Livers Demonstrate Shear Strain Softening and Compression Stiffening: a Model for Soft Tissue Mechanics.

Perepelyuk, L. Chin, X. Cao, A. V. Oosten, V. B. Shenoy, P. A. Janmey, and R. G. Wells.

PLOS ONE, DOI: 10.1371/journal.pone.0146588 JANUARY 2016


Mechanical signaling coordinates the embryonic heartbeat.

K.K. Chiou, J.W. Rocks, C. Yingxian Chen, S. Cho, K.E. Merkus, A. Rajaratnam, P. Robison, M. Tewari, K. Vogel, S.F. Majkut, B.L. Prosser, D.E. DischerA.J. Liu.

Proceedings of the National Academy of Sciences 113(32):8939-44 (2016).


Membrane shape instability induced by protein crowding.

Chen Z., Atefi E., Baumgart T.

Biophysical Journal  111, 9, p 1823 (2016)


Filomicelles from aromatic di-block copolymers increase paclitaxel-induced tumor cell death and aneuploidy compared to aliphatic copolymer.

P.R. Nair, K. S. Anbazhagan, K.R. Spinler, M.R. Vakili A. Lavasanifar, D.E. Discher.

Nanomedicine 11: 1551-1569 (2016).


Mechanotransduction In Cancer.

Chin, Y. Xia, D.E. Discher, P.A. Janmey.

Current Opinion in Chemical Engineering 14: 951–960 (2016).


Nuclear lamins in cancer.

Irianto, C. Pfeifer, I.L. Ivanovska, J. Swift, and D.E. Discher.

Cell and Molecular Bioengineering 9: 258-267 (2016).


Thermodynamic free energy methods to investigate shape transitions in bilayer membranes.

N. Ramakrishnan, R. W. Tourdot, R. Radhakrishnan,

International Journal of Advances in Engineering Sciences and Applied Mathematics, 8: 88-100 (2016)


A chemo-mechanical model for nuclear morphology and stresses during cell transendothelial migration.

Cao, E. Moeendarbary, P. Isermann, P. M. Davidson, X. Wang, M. B. Chen, A. K. Burkart, J. Lammerding, R. D. Kamm, and V. B. Shenoy.



Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling.

S. Liu, H. Wang, C. R. Copeland, C. S. Chen, V. B. Shenoy*, and D. H. Reich*.



Response of biopolymer networks governed by the physical properties of cross-linking molecules.

Wei, Q. Zhu, J. Qian, Y. Lin, and V. B. Shenoy.

SOFT MATTER, 12:2537-2541 MARCH 2016


Detyrosinated Microtubules Buckle and Bear Load in Contracting Cardiomyocytes.

Robison, M. A. Caporizzo, H. Ahmadzadeh, A. I. Bogush, C. Y. Chen, K. B. Margulies, V. B. Shenoy, and B. L. Prosser.

SCIENCE, 352: 6284 APRIL 2016


Harnessing Cellular-Derived Forces in Self-Assembled Microtissues to Control the Synthesis and Alignment of ECM.

Y. Schell, B. T. Wilks, M. Patel, C. Franck, V. Chalivendra, X. Cao, V. B. Shenoy, and J. Morgan.




Constricted cell migration causes nuclear lamina damage, DNA breaks, and squeeze-out of repair factors

Jerome Irianto, Charlotte R Pfeifer, Yuntao Xia, Avathamsa Athirasala, Irena L Ivanovska, Roger A Greenberg, Dennis E Discher

bioRxiv 035626; doi:


Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor.

P.C.D.P. Dingal, A.M. Bradshaw, S. Cho, M. Raab, A. Buxboim, J. Swift, and D.E. Discher.

Nature Materials 14: 951–960 (2015).


Stem cell mechanobiology – diverse lessons from bone marrow.

I.L. Ivanovska, J-W. Shin, J. Swift, and D.E. Discher.

Trends in Cell Biology 25:523-32 (2015).


Myosin-II repression favors pre/pro-platelets, but shear-activation generates platelets and fails in macrothrombocytopenia.

K.R. Spinler, J-W. Shin, M.P. Lambert, D.E. Discher.

Blood 125:525-33 (2015).


Cell Rigidity and Shape override CD47’s ‘Self’ signaling in Phagocytosis by Hyperactivating Myosin-II.

N.G. Sosale, T. Rouhiparkouhi, A.M. Bradshaw, R. Dimova, R. Lipowsky, and D.E. Discher.

Blood 125:542-52 (2015).


Cell-mediated fiber recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments.

Baker, B. Trappmann, W. Wang, M. S. Sakar, I. Kim, V. B. Shenoy, J. Burdick, and C. S. Chen
NATURE MATERIALS, 14, 1262-1268, 2015


ATM dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition.

Harding SM, Boiarsky J, and Greenberg RA.

Cell Reports S2211-1247 2015 (PMC4607662)


Mechanical effects of dynamic binding between tau proteins on axonal microtubules during traumatic brain injury: predictions from a computational model.

Ahmadzadeh, D. H. Smith, and V. B. Shenoy.

BIOPHYSICAL JOURNAL, 109(11):2328-2337, 2015


A chemo-mechanical model for extracellular matrix and nuclear rigidity regulated size of focal adhesion plaques.

Cao, Y. Lin, T. P. Driscoll, J. Franco-Barraza, E. Cukierman, R. L. Mauck, and V. B. Shenoy
BIOPHYSICAL JOURNAL, 109(9):1807-1817, 2015


A chemo-mechanical free-energy-based approach to model durotaxis and extracellular stiffness-dependent contraction and polarization of cells.

V.B. Shenoy, H. Wang and X. Wang.



Application of a free energy landscape approach to study tension dependent bilayer tubulation mediated by curvature inducing proteins,

R. W. Tourdot, N. Ramakrishnan, T. Baumgart, R. Radhakrishnan,

Physical Review E, 92, 042715. (2015)


Phenomenology based multiscale models as tools to understand morphological transitions in cell membranes.

Ramakrishnan, R. Radhakrishnan,

Advances in Planar Lipid Bilayers and Liposomes – Elsevier, 2015,

ISSN 1554-4516, Vol 22, pp 129-175. DOI: 10.1016/bs.adplan.2015.06.004